This alcohol-free spirit promises to give you all the good bits of booze – and none of the bad

Cast your mind back to a time when you could go on a night out.

You’d start with a G&T or a glass of bubbles as you put on your mascara. Then, drinks out at a bar: a couple of cocktails or pints of lager. It could easily end up with Jagers on the dancefloor, or tequila shots at an afterparty – and most likely, a nauseous train journey to work the next morning, or a full English fry-up to kick off a Saturday on the sofa.

Alcohol is ingrained into the way that we socialise. 82% of British adults drink alcohol regularly and our obsession with ‘the pub’ made itself painfully clear as lockdowns came and went – alongside trips to the local boozer – throughout 2020.

Yet there’s growing cultural awareness about the dangers of excessive alcohol consumption. Alcohol Change UK reports a steady rise in non-drinkers between the ages of 16 and 24, and the non-profit predicted that 6.5 million people would take part in Dry January this month. That’s up from 3.9 million in 2020, and just 4,000 when the concept launched in 2013.

However, many of us have scrapped Dry January as we struggle with the latest UK lockdown. YouGov figures found that a third of people pledging to stay off booze this month had given up in the first week, and Waitrose beer sales were up 49% after week one of lockdown.

For many of us, to give up alcohol under lockdown is to lose one of the remaining small pleasures getting us through it. But the British public is caught in an arm wrestle between the knowledge that alcohol is harmful – in 2019, alcohol-related hospital admissions in the UK had reached an annual peak of 1.26 million – and the fact that drinking it is so pervasive in our society. For many, it’s also very enjoyable.

There’s a solution to all this.

What if we told you that you could enjoy all the positive effects of alcohol, but end up with no hangover or damage to your health?

It sounds like something from a sci-fi, but a drink like this has been invented. You can buy it online right now.

Sentia Spirits is the brainchild of David Nutt, Professor of Neuropsychopharmacology at Imperial College London. Once a government drugs advisor, Nutt was sacked in 2009 for highlighting the hypocrisy of drug policy in the UK. Famously, he presented evidence that alcohol is more harmful to society than heroin or crack.

‘Alcohol is the most harmful drug in the UK,’ says Nutt, now.

‘It’s the most common drug that we encounter causing damage to people, in every branch of medicine. As a doctor and scientist, my life’s work has been trying to reduce the damage of alcohol – and this is a way of doing it.’

The science behind Sentia

Sentia is a non-alcoholic drink made of a licensed, ‘Botanical GABAergic Blend’ from Nutt’s team at GABA Labs.

There are other botanical drinks on the market – like Three Spirit Drinks, which uses ingredients like cacao and lion’s mane for mood-boosting, energising effects. Not to mention the slew of non-alcoholic beers, wines and spirits already flooding the market.  

But Sentia does much more than mimic the taste and texture of an alcoholic spirit: it actually gets you tipsy. The magic recipe has been developed from decades of scientific research into the way that alcohol affects the brain.

‘Sentia is the first drink to replicate the pro-social effects of alcohol, by targeting the brain system that mediates them,’ says Nutt.

‘It started in 1980 when I was doing my PhD. I discovered an antidote to alcohol and thought, this is amazing – you could take it at the end of a night out, get sober and find your way home.

‘But my professor said, what’s the point of that? Isn’t the alcohol still going to be killing your liver? And won’t people just drink more?

‘Nevertheless, it was the first step into discovering how alcohol works in your brain.

‘The main calming transmitter in your brain is called GABA [gamma-Aminobutyric acid]. Alcohol enhances GABA, which is why it relaxes you and makes you more convivial.

‘Over the last 40 years or so we’ve been working to understand the GABA system in the brain. It turns out it’s a very sophisticated system with multiple parts, and alcohol stimulates them all. We’re trying to stimulate the good effects of alcohol, without the bad.’

This research has branched into two directions. The long-term project is the invention of a synthesised, alcohol-alternative molecule. Then there’s Sentia: the herbal alternative, which took the past two years to create.

‘Hopefully it’ll raise enough money to fund the more expensive, chemistry part,’ says Nutt.

‘We’re in the process of raising funds to take the molecules through safety testing, so they can become foodstuffs ingredients in a few years’ time, but that costs millions of pounds.

‘So to raise that money and develop the concept, we started looking for botanical ingredients that would work in a similar way to GABA. We identified four plants that in combination, and with uptake enhancers, produced this effect.

‘All the ingredients are either foods or food additives, so they’re covered by safety standards already.’

The herbal combination is top secret for now, but I wanted to get my hands on a bottle.

What’s drinking Sentia like?

In a glass, bell-jar-style bottle, Sentia looks like a boutique gin or whisky – and at £30 for a 50cl bottle, the price tag more-or-less matches that description. It’s a rich magenta in colour, complementing its lavender label and pouring out thick and juice-like.

It doesn’t have a strong smell – just a hint of botanicals. Neat, over three cubes of ice, its full flavour comes through: a strong, herbaceous first taste, followed by sweetness, then a clove-like aftertaste. It’s a bit like mulled wine. Add tonic water or lemonade and it becomes a sweet and tangy aperitif, bold enough in flavour and texture to easily hold up against any other mixed drink I might rustle up from the cupboard.

After one glass, I feel just like I would after a gin and tonic (my usual go-to). My cheeks are slightly flushed and I’m definitely more relaxed. After a second, I’m a bit giggly and chatty. How far can I take this, I wonder? I drink a third, then a fourth, but the sensation doesn’t progress much further. Unlike with alcohol, you can’t get beyond that initial tipsy feeling.

‘We want you to get a good effect that plateaus,’ says Nutt, confirming that it’s not possible to get wasted on Sentia.

‘The effects might last longer, but it’s not poisoning the body in the same way that alcohol does.’

Could you drink Sentia as a designated driver, or underage, or pregnant?

‘We suggest over 18s only and have no data for pregnancy or breastfeeding yet,’ says Nutt.

And while there’s no evidence of impairment with Sentia, the team won’t recommend it for designated drivers as people might be affected by it differently.

On the plus side, Sentia’s been found to improve sleep in some people and you don’t get the munchies – which means no more 3am kebabs. Plus, I woke up the next morning feeling entirely hangover-free, which would not have been the case had I swapped those Sentia measures for vodka.

The future of drinking?

Post-lockdown, it might not be long before you spot Sentia in delis, specialist drinks shops or behind the bar at high-end cocktail spots (not least at Pulp, a bar that Nutt co-owns in Ealing). Going forward, the range of flavours or effects could expand, or it could enter the world of mixology, especially if a clear-liquid version is made available. All are in the works at GABA Labs.

It’s safe to say there’s a market for all this. In 2020, 11 new non-alcoholic spirit brands launched in the UK market, making a grand total of 42. As fewer millennials choose to drink alcohol, the market for alternatives is growing drastically, including variations from big drinks brands like Gordon’s and Martini. It’s similar to Big Tobacco’s investment in e-cigarettes, or the backing of the meat industry for vegan mock meats.

‘Let’s face it, the drinks industry has known for hundreds of years that alcohol is not very good for your body,’ says Nutt.

‘Now that the rest of the world has wisened up to that, it would make a lot of sense for them to have drinks like this as part of their portfolio. I suspect many alcohol companies will want to join us. It makes commercial sense.’

There’s still a place for recreating comforting classics with non-alcoholic spirits. Gordon’s deliciously juniper-infused 0.0% spirit went on the market just before Christmas, and – like Seedlip – it shows that a grown-up, treaty drink doesn’t have to involve booze.

But these drinks will always be missing something.

‘80% of adults drink alcohol,’ says Nutt.

‘Why? Because they enjoy the sensation. For most people, many of their pleasant social interactions have occurred alongside alcohol.

‘All we’re trying to do is give them something that will do what they want, but with very, very reduced risks of harm.’

There’s nothing wrong with enjoying the sensation of alcohol, and GABA Labs is certainly not trying to replace alcohol for good. But an actual alcohol alternative, that makes Dry January fun? I’ll drink to that.

Original post:


Are psychedelic drugs the future of treating mental illness?

For many of us, the words MDMA, ketamine and magic mushrooms mean party drugs, illicit substances or a throwback to the swinging sixties.

But these stereotypes mask the truth: pychedelic drugs are on their way to becoming official treatments for mental health disorders, such as post-traumatic stress disorder (PTSD), depression, addiction, and anxiety.

In January 2021, the UK’s first medical psychedelic clinic is due to open in Bristol, run by Awakn – an organisation working to integrate psychedelic medicine into mainstream mental healthcare. The clinic will offer ketamine-assisted psychedelic psychotherapy, which is legal as ketamine is medically licensed as an anaesthetic.

Alongside that service (which has the capacity to treat 30-40 people each month), the clinic will offer training for psychedelic therapists and undertake psychedelic research into MDMA and psilocybin (the psychedelic compound found in magic mushrooms), which are not currently legal for use in psychotherapy.

Meanwhile, on December 17, Britain’s first psychedelic healthcare fund launched by venture capitalist Neo Kuma Ventures. The fund has already attracted millions of pounds in investment into psychedelic medicines to treat unmet needs in mental healthcare.

Interest in psychedelic healthcare is growing globally, particularly in the US. In November 2020, the state of Oregon voted to legalise psilocybin for therapeutic use, kickstarting a two-year process of working out protocols for offering psychedelic psychotherapy as a mainstream treatment by 2022. It also separately voted to decriminalise possession of small amounts of all drugs.

‘While we’ve done much of the research into psychedelic psychotherapy in Britain, the US is clearly ahead of us,’ says David Nutt, Professor of Neuropsychopharmacology at Imperial College London and the UK’s leading voice on drug reform.

‘They’re also way ahead of us with cannabis.

‘While in the UK the government controls everything, America’s devolved healthcare means that the liberated, sensible states can vote for these changes.’

The concept of psychedelic drugs being used to treat mental health conditions hasn’t yet entered mainstream consciousness, but the evidence for its benefits is striking. A study by Dr Ben Sessa, who leads the scientific team at the new Awakn clinic alongside Professor Nutt, found that MDMA-assisted psychotherapy is hugely effective in treating alcohol addiction, so often rooted in past trauma.

MDMA and psilocybin are illegal, schedule 1 substances, meaning that a Home Office licence is required for their production, possession or supply. While this complicates research projects in this field, it’s legal to use these drugs in clinical trials, despite them being illegal to prescribe outside of a trial and for recreational use.

London-based mental healthcare company COMPASS is currently undertaking the largest global clinical trial for psilocybin therapy to treat depression, recruiting 216 patients across 21 sites in Europe, the US and Canada.

‘If it’s approved, it gets into the system and is proved to be safe and effective for treating depression,’ says Tracy Yeung, Chief Communications Officer at COMPASS Pathways.

‘We’re generating the evidence that can be used to get into national health systems. At the moment, we’re in the stage of rigorous clinical trials to show that this treatment works, to give people the confidence to eventually use them as clinical therapy.

‘There are 100 million people in the world with treatment-resistant depression – that’s a huge number. It’s a huge economic burden and burden on society and it’s unfair that so many people currently don’t have any options.’

According to Professor Nutt, the ‘war on drugs’ that’s been waging since the 70s is responsible for this burden, by setting back the research into psychedelic medical treatments, and preventing adequate treatments by at least 50 years.

‘There is no country in the world where synthetic psychedelics are legal,’ he says. ‘This has caused about a million excess deaths a year, due to the failures of being able to access medication.’

What about cannabis?                           

In 2018, cannabis was legalised for medical use in the UK. But two years on, half of Brits are unaware of the law change, and access to the treatment remains low.

‘You need to be a specialist doctor to prescribe medical cannabis, and we only have about 40 of those specialists across the country,’ says Professor Nutt, who is also currently leading Project Twenty21, an audit aiming to enrol 20,000 patients being prescribed medical cannabis to produce more research on its efficacy.

‘The plan with Project Twenty21 is to gather data to show that doctors prescribing medical cannabis get good results.’

Cannabis is proven an effective treatment for pain disorder, PTSD, anxiety, addiction, depression, multiple sclerosis, Tourette’s syndrome and epilepsy. A study released by Professor Nutt’s team this week shows that medical cannabis can reduce seizures in patients with severe epilepsy by 97%. But even with these staggering figures, it remains unlikely for a patient to be prescribed medical cannabis by the NHS.  

Why might psychedelics be effective for treating mental health conditions?

Traditional treatments for mental health disorders such as depression, anxiety and PTSD include talking therapies, like Cognitive Behavioural Therapy (CBT), and antidepressants such as SSRIs. But these therapies treat the symptoms of mental health conditions, rather than addressing their cause – which is often rooted in trauma, ranging from childhood abuse to PTSD in soldiers returning from conflict.

‘I like psychedelics because I don’t like psychiatric drugs,’ says Dr Sessa, who believes that MDMA could be the mental healthcare equivalent of antibiotics in terms of its groundbreaking efficacy.

‘We’ve got a huge backlog of chronic, lifelong mental disorder that we treat with maintenance therapy. SSRIs and mood stabilisers just paper over the cracks. Psychedelic psychotherapy is the best pharmacology we have to treat these disorders.

‘Psychiatry has painted itself into a corner where we don’t talk about ‘cure’, and I don’t think that’s good enough. Other branches of medicine wouldn’t accept the poor outcomes we accept in psychiatry. It’s like breaking your ankle and being prescribed paracetamol for the rest of your life.

‘But with psychedelics, we can take a person in their 20s or 30s with a history of severe childhood abuse and a severe mental disorder like PTSD, and we can completely cure them and send them on their way.

‘It’s a radical new paradigm shift for mental health.’

It’s important to note that introducing psychedelic psychotherapies could save the NHS a serious amount of money. A study by MAPS in the USA found that if public healthcare payers or private insurers made MDMA-assisted psychotherapy available to just 1,000 patients, healthcare costs would be reduced by $103.2million over 30 years.

How does a psychedelic therapy session go down?

All psychotherapists experimenting with psychedelic treatments are quick to remind us that taking these drugs in a clinical setting is nothing like experimenting with them recreationally. In medical MDMA and psilocybin trials, as well as with ketamine-assisted therapy at Awakn’s upcoming Bristol clinic, psychedelics are administered periodically during a weeks-long course of psychotherapy.

‘It’s not at all just taking some psilocybin at home,’ says Yeung.

‘It’s combined with psychological support from a specially trained therapist, in a special clinic. Before you go for your administration session you have preparatory sessions to explain what you’ll go through.

‘On the day of the experience, you take your psilocybin, you lie on a bed with eye shades on and listen to a carefully curated playlist, and sit with the therapists who will be there throughout the whole experience to support you. Then afterwards you’ll speak to the therapist about the experience.’

Dr Sessa also points out that while ketamine-assisted therapy already exists to treat depression, the Awakn clinic will be the UK’s first to use it alongside psychotherapy.

‘In 99% of ketamine clinics around the world, the psychedelic aspect is seen as an annoying side effect. The patient gets hooked up to a drip for a couple of hours and lies there with no interaction with anyone.

‘In our clinic, the patients are essentially on a seven-week course of regular psychotherapy, in which they take ketamine on four occasions and have psychotherapy during the ketamine sessions.’

MDMA and psilocybin therapy sessions can last for six to eight hours – a full day of treatment – while ketamine is faster-acting, and lasts up to 90 minutes in a therapeutic session. After your treatment, you’ll take a couple of hours’ recovery time before heading home.

The bottom line

The NHS’s reluctance to prescribe medical cannabis reflects the UK’s drug prohibition laws at large. This approach prolongs the process of helping patients with treatment-resistant mental health disorders.

‘Drug policy is connected to our work,’ says Dr Sessa.

‘Prohibition relies on a substance being dangerous. But you undermine the dangerous aspect of a drug if a doctor is prescribing it.

‘Our prohibition drug laws in the UK have been entirely ineffective at their job, which was to control these substances. After 50 years of prohibition, drugs haven’t gone away.

‘In fact, far more people are using psychedelics now than they were in the 60s.’

And as long as medical access to psychedelics are illegal, people will self-administer them from the black market – sometimes to treat their own mental health concerns.

‘I was in talking therapies for nearly two decades, and it was gruelling,’ says Laura How, a therapist and counsellor near Bristol.

‘I experienced an abusive childhood and for people who have experienced complex trauma, I’m not sure if talking therapy is always enough.

‘I took antidepressants, but they didn’t work. But when I started taking psilocybin, I stopped getting long periods of depression. I started to feel lighter and lighter, after feeling heavy my whole life.’